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To make matters worse, crowded into the adjoining cell like so many desperate immigrants, and separated from you by nothing more than the thin permeable wall of your own fear, are all the anticipated rejections of your life.

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And eventually, if you have been a diligent enough student and not wasted your time in dreaming, you come to understand that it is not the rejections that make this a prison, not the defeats, but rather your own grim expectation of defeat; not life but its bodily outline drawn in chalk, where the body should be but isn't, where it once was, this ingrained cowardly pessimism, this relentless betting against love and instinct.

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Don Juan in Hankey, PA 3. Martin did her doctoral work in the laboratory of Harry Rubin, where she pursued several projects aimed at elucidating the mechanisms that control the growth of fibroblasts in vitro.

She completed her Ph. It was during that time that she married Steven Martin, a British scientist who had come to Berkeley to do postdoctoral work in the Rubin laboratory.

After completing her graduate studies, Martin and her husband moved to London. In , she worked with Martin J. Evans at University College London.

Evans was then working with teratocarcinomas a type of tumor , which are of interest because they contain pluripotent stem cells known as embryonal carcinoma, [EC] cells from which all the differentiated cell types in the tumor arise.

During the two years she spent working in Evans' laboratory, Martin devised a protocol for isolating and maintaining EC cells in the undifferentiated state and for differentiating them in vitro.

This work [2] laid the groundwork for the future isolation of pluripotent stem cells from normal mouse and human embryos. In , Martin and her husband returned to Berkeley, where he took up a faculty position at UCB and she began a year of postdoctoral work with Charles J.

During this period she and her colleagues demonstrated that female EC cells had two active X chromosomes and could be used to study X-chromosome inactivation in vitro.

In Martin joined the UCSF faculty and established her own laboratory, which was active until Her first major accomplishment was the isolation of pluripotent stem cells from normal mouse blastocysts.

Subsequently, using sophisticated genetic methods that she helped to pioneer, Martin and her colleagues demonstrated the importance of FGF signaling in the development of many organs including the limb.

She also was responsible, in collaboration with a software engineer, Jonathan Scoles, for the development of a database that provides a description of all the genetically altered mice housed at UCSF.

This online resource helps researchers determine if mice carrying a particular genetic alteration are available at UCSF and to find out whom to contact about the possibility of obtaining them.

Access to this information has saved investigators considerable time and money in acquiring mouse models for their studies and been a stimulus to collaboration between researchers.

She has delivered numerous special lectures, including the George W. Brumley Jr.

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